Investigating novel mechanisms of drug resistance in Plasmodium falciparum

• Main Author: Ng, Shyan Poh Shuang
• Other Authors: Peter Preiser
• Format: Final Year Project
• Language: English
• Published: Nanyang Technological University 2021
• Subjects: Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/153285
• Institution: Nanyang Technological University

Due to widespread drug resistance undermining antimalarial eradication efforts, there is an urgency to develop new drugs. Drug repurposing was adopted, with drug L selected as a candidate drug. Lack of observable hemozoin, which is a unique resistant phenotype, and discovery of A257T mutation in Pla...