Gold nanorod assisted enhanced plasmonic detection scheme of COVID-19 SARS-CoV-2 spike protein

• Main Authors: Das, Chandreyee Manas, Guo, Yan, Yang, Guang, Kang, Lixing, Xu, Gaixia, Ho, Ho-Pui, Yong, Ken-Tye
• Other Authors: School of Electrical and Electronic Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Engineering::Nanotechnology; COVID-19; Gold Nanorods
• Online Access: https://hdl.handle.net/10356/153303
• Institution: Nanyang Technological University

The beautiful interplay between light and matter can give rise to many striking physical phenomena, surface plasmon resonance (SPR) being one of them. Plasmonic immunosensors monitor refractive index changes that occur as a result of specific ligand–analyte or antibody–antigen interactions taking place on the sensor surface. The coronavirus disease (COVID-19) pandemic has jeopardized the entire world and has resulted in economic slowdown of most countries. In this work, a model of a sandwich plasmonic biosensor that utilizes gold nanorods (Au NRs) for the detection of COVID-19 SARS-CoV-2 spike protein is presented. Simulation results for different prismatic configurations for the basic Kretschmann layout are presented. It is found that a BK7 glass prism-based SPR sensor has an incremental sensitivity of 111.11 deg RIU−1. Additionally, using Comsol Multiphysics the electric field enhancement observed for various aspect ratios and layouts of Au NRs are discussed in depth.