Role of membrane stretch in adsorption of antiviral peptides onto lipid membranes and membrane pore formation

• Main Authors: Chng, Choon-Peng, Cho, Nam-Joon, Hsia, K. Jimmy, Huang, Changjin
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences::Biophysics; Antiviral Peptide; Membrane Stretch
• Online Access: https://hdl.handle.net/10356/153448
• Institution: Nanyang Technological University

Many medically important viruses are enveloped viruses, which are surrounded by a structurally conserved, host-derived lipid membrane coating. Agents that target and disrupt this membrane coating could potentially function as broad-spectrum antiviral drugs. The amphipathic α-helical (AH) peptide der...