Site-specific peroxidation modulates lipid bilayer mechanics

• Main Authors: Chng, Choon-Peng, Sadovsky, Yoel, Hsia, K. Jimmy, Huang, Changjin
• Other Authors: School of Mechanical and Aerospace Engineering
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Physics::Descriptive and experimental mechanics; Science::Biological sciences::Biophysics; Lipid Peroxidation; Molecular Simulation
• Online Access: https://hdl.handle.net/10356/153450
• Institution: Nanyang Technological University

Peroxidation of plasma membranes, characterized by oxidative attack of lipidic carbon–carbon double bonds in unsaturated fatty acids, has been identified as an important biochemical event in multiple pathological conditions, including neurodegenerative diseases, atherosclerosis, diabetes, preeclamp...