Mechanically induced integrin ligation mediates intracellular calcium signaling with single pulsating cavitation bubbles

• Main Authors: Li, Fenfang, Park, Tae Hyun, Sankin, George, Gilchrist, Christopher, Liao, Defei, Chan, Chon U., Mao, Zheng, Hoffman, Brenton D., Zhong, Pei
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Intracellular Calcium Signaling; Cavitation Bioeffects
• Online Access: https://hdl.handle.net/10356/153595
• Institution: Nanyang Technological University

Therapeutic ultrasound or shockwave has shown its great potential to stimulate neural and muscle tissue, where cavitation microbubble induced Ca2+ signaling is believed to play an important role. However, the pertinent mechanisms are unknown, especially at the single-cell level. Particularly, it is...