Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3)

• Main Authors: Li, Kuohan, Zheng, Jie, Wirawan, Melissa, Trinh, Nguyen Mai, Fedorova, Olga, Griffin, Patrick R., Pyle, Anna M., Luo, Dahai
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2021
• 主題: Science::Medicine; Science::Biological sciences; Germ-Line Development; Rig-I
• 在線閱讀: https://hdl.handle.net/10356/153718

DRH-3 is critically involved in germline development and RNA interference (RNAi) facilitated chromosome segregation via the 22G-siRNA pathway in Caenorhabditis elegans. DRH-3 has similar domain architecture to RIG-I-like receptors (RLRs) and belongs to the RIG-I-like RNA helicase family. The molecul...