RIG-I activation by a designer short RNA ligand protects human immune cells against dengue virus infection without causing cytotoxicity

• Main Authors: Fink, Katja, Ho, Victor, Yong, Hui Yee, Chevrier, Marion, Narang, Vipin, Lum, Josephine, Toh, Ying-Xiu, Lee, Bernett, Chen, Jinmiao, Tan, Ern Yu, Luo, Dahai
• Other Authors: Williams, Bryan RG.
• Format: Article
• Language: English
• Published: 2019
• Subjects: Dengue; RIG-I; Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/106854; http://hdl.handle.net/10220/49675
• Institution: Nanyang Technological University

Virus-derived double-stranded RNA (dsRNA) molecules containing a triphosphate group at the 5′ end are natural ligands of retinoic acid-inducible gene I (RIG-I). The cellular pathways and proteins induced by RIG-I are an essential part of the innate immune response against viral infections. Starting...