RIG-I activation by a designer short RNA ligand protects human immune cells against dengue virus infection without causing cytotoxicity
Virus-derived double-stranded RNA (dsRNA) molecules containing a triphosphate group at the 5′ end are natural ligands of retinoic acid-inducible gene I (RIG-I). The cellular pathways and proteins induced by RIG-I are an essential part of the innate immune response against viral infections. Starting...
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| Main Authors: | , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2019
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| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/106854 http://hdl.handle.net/10220/49675 |
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| Institution: | Nanyang Technological University |
| Language: | English |