Intranasal delivery of RIG-I agonist drives pulmonary myeloid cell activation in mice

• Main Authors: Nair, Sajith, Wu, Yilun, Nguyen, Trinh Mai, Fink, Katja, Luo, Dahai, Ruedl, Christiane
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Innate Immunity; Intranasal Vaccination
• Online Access: https://hdl.handle.net/10356/161476
• Institution: Nanyang Technological University

Viral respiratory infections cause substantial health and economic burden. There is a pressing demand for efficacious vaccination strategies and, therefore, a need for a better understanding of the mechanisms of action of novel potential adjuvants. Here we investigated the effect of a synthetic RIG-...