A human antibody neutralizes different flaviviruses by using different mechanisms

A human antibody neutralizes different flaviviruses by using different mechanisms

Human antibody SIgN-3C neutralizes dengue virus (DENV) and Zika virus (ZIKV) differently. DENV:SIgN-3C Fab and ZIKV:SIgN-3C Fab cryoelectron microscopy (cryo-EM) complex structures show Fabs crosslink E protein dimers at extracellular pH 8.0 condition and also when further incubated at acidic endoso...

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Bibliographic Details
Main Authors: Zhang, Shuijun, Loy, Thomas, Ng, Thiam-Seng, Lim, Xin-Ni, Chew, Valerie Shyn-Yun, Tan, Ter Yong, Xu, Meihui, Kostyuchenko, Victor A., Tukijan, Farhana, Shi, Jian, Fink, Katja, Lok, Shee-Mei
Other Authors: School of Biological Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Dengue Virus
Zika Virus
Online Access:https://hdl.handle.net/10356/145978
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/145978

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