A human antibody neutralizes different flaviviruses by using different mechanisms

• Main Authors: Zhang, Shuijun, Loy, Thomas, Ng, Thiam-Seng, Lim, Xin-Ni, Chew, Valerie Shyn-Yun, Tan, Ter Yong, Xu, Meihui, Kostyuchenko, Victor A., Tukijan, Farhana, Shi, Jian, Fink, Katja, Lok, Shee-Mei
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Biological sciences; Dengue Virus; Zika Virus
• Online Access: https://hdl.handle.net/10356/145978
• Institution: Nanyang Technological University

Human antibody SIgN-3C neutralizes dengue virus (DENV) and Zika virus (ZIKV) differently. DENV:SIgN-3C Fab and ZIKV:SIgN-3C Fab cryoelectron microscopy (cryo-EM) complex structures show Fabs crosslink E protein dimers at extracellular pH 8.0 condition and also when further incubated at acidic endoso...