Analysis of aneuploidy spectrum from whole-genome sequencing provides rapid assessment of clonal variation within established cancer cell lines

• Main Authors: Ahmed Ibrahim Samir Khalil, Chattopadhyay, Anupam, Sanyal, Amartya
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Computer science and engineering; Science::Biological sciences; Aneuploidy Spectrum; Cancer Cell Lines
• Online Access: https://hdl.handle.net/10356/153768
• Institution: Nanyang Technological University

BACKGROUND: The revolution in next-generation sequencing (NGS) technology has allowed easy access and sharing of high-throughput sequencing datasets of cancer cell lines and their integrative analyses. However, long-term passaging and culture conditions introduce high levels of genomic and phenotypi...