Changes in cerebrospinal fluid balance of TNF and TNF receptors in naïve multiple sclerosis patients : early involvement in compartmentalised intrathecal inflammation

• Main Authors: Magliozzi, Roberta, Pezzini, Francesco, Pucci, Mairi, Rossi, Stefania, Facchiano, Francesco, Marastoni, Damiano, Montagnana, Martina, Lippi, Giuseppe, Reynolds, Richard, Calabrese, Massimiliano
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2021
• Subjects: Science::Medicine; Multiple Sclerosis; Tumor Necrosis Factor (TNF)
• Online Access: https://hdl.handle.net/10356/153838
• Institution: Nanyang Technological University

An imbalance of TNF signalling in the inflammatory milieu generated by meningeal immune cell infiltrates in the subarachnoid space in multiple sclerosis (MS), and its animal model may lead to increased cortical pathology. In order to explore whether this feature may be present from the early stages...