Bulges in left-handed G-quadruplexes

Bulges in left-handed G-quadruplexes

G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the...

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Bibliographic Details
Main Authors: Das, Poulomi, Ngo, Khac Huy, Winnerdy, Fernaldo Richtia, Maity, Arijit, Bakalar, Blaž, Mechulam, Yves, Schmitt, Emmanuelle, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2021
Subjects:
Science::Biological sciences
Crystallography
X-Ray
Online Access:https://hdl.handle.net/10356/153872
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Institution: Nanyang Technological University
Language: English
Description
Summary:G-quadruplex (G4) DNA structures with a left-handed backbone progression have unique and conserved structural features. Studies on sequence dependency of the structures revealed the prerequisites and some minimal motifs required for left-handed G4 formation. To extend the boundaries, we explore the adaptability of left-handed G4s towards the existence of bulges. Here we present two X-ray crystal structures and an NMR solution structure of left-handed G4s accommodating one, two and three bulges. Bulges in left-handed G4s show distinct characteristics as compared to those in right-handed G4s. The elucidation of intricate structural details will help in understanding the possible roles and limitations of these unique structures.

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