A synbiotic intervention modulates meta-omics signatures of gut redox potential and acidity in elective caesarean born infants

• Main Authors: Lay, Christophe, Chu, Collins Wenhan, Purbojati, Rikky Wenang, Acerbi, Enzo, Drautz-Moses, Daniela Isabel, de Sessions, Paola Florez, Jie, Song, Ho, Eliza, Kok, Yee Jiun, Bi, Xuezhi, Chen, Shuwen, Mak, Shi Ya, Chua, Mei Chien, Goh, Anne E. N., Chiang, Wen Chin, Rao, Rajeshwar, Chaithongwongwatthana, Surasith, Khemapech, Nipon, Chongsrisawat, Voranush, Martin, Rocio, JULIUS Study Group, Guus Roeselers, Ho, Ying Swan, Hibberd, Martin L., Schuster, Stephan Christoph, Knol, Jan
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Environmental engineering; Microbiome; Infant
• Online Access: https://hdl.handle.net/10356/153948
• Institution: Nanyang Technological University

The compromised gut microbiome that results from C-section birth has been hypothesized as a risk factor for the development of non-communicable diseases (NCD). In a double-blind randomized controlled study, 153 infants born by elective C-section received an infant formula supplemented with either synbiotic, prebiotics, or unsupplemented from birth until 4 months old. Vaginally born infants were included as a reference group. Stool samples were collected from day 3 till week 22. Multi-omics were deployed to investigate the impact of mode of delivery and nutrition on the development of the infant gut microbiome, and uncover putative biological mechanisms underlying the role of a compromised microbiome as a risk factor for NCD.