Disruption of the Pseudomonas aeruginosa Tat system perturbs PQS-dependent quorum sensing and biofilm maturation through lack of the Rieske cytochrome bc₁ sub-unit

• Main Authors: Soh, Eliza Ye-Chen, Smith, Frances, Gimenez, Maxime Rémi, Yang, Liang, Vejborg, Rebecca Munk, Fletcher, Matthew, Halliday, Nigel, Bleves, Sophie, Heeb, Stephan, Cámara, Miguel, Givskov, Michael, Hardie, Kim R., Tolker-Nielsen, Tim, Ize, Bérengère, Williams, Paul
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering (SCELSE)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Geology; Ampicillin; Antibiotic Agent
• Online Access: https://hdl.handle.net/10356/154009
• Institution: Nanyang Technological University

Extracellular DNA (eDNA) is a major constituent of the extracellular matrix of Pseudomonas aeruginosa biofilms and its release is regulated via pseudomonas quinolone signal (PQS) dependent quorum sensing (QS). By screening a P. aeruginosa transposon library to identify factors required for DNA relea...