High-payload buccal delivery system of amorphous curcumin-chitosan nanoparticle complex in hydroxypropyl methylcellulose and starch films

• Main Authors: Lim, Li Ming, Hadinoto, Kunn
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Chemical engineering; Curcumin; Nanoparticle Complex
• Online Access: https://hdl.handle.net/10356/154017
• Institution: Nanyang Technological University

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR's poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubi...