High-payload buccal delivery system of amorphous curcumin-chitosan nanoparticle complex in hydroxypropyl methylcellulose and starch films

• Main Authors: Lim, Li Ming, Hadinoto, Kunn
• 其他作者: School of Chemical and Biomedical Engineering
• 格式: Article
• 語言: English
• 出版: 2022
• 主題: Engineering::Chemical engineering; Curcumin; Nanoparticle Complex
• 在線閱讀: https://hdl.handle.net/10356/154017

Oral delivery of curcumin (CUR) has limited effectiveness due to CUR's poor systemic bioavailability caused by its first-pass metabolism and low solubility. Buccal delivery of CUR nanoparticles can address the poor bioavailability issue by virtue of avoidance of first-pass metabolism and solubi...