Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk

Modifiable risk factors are of interest for chronic disease prevention. Few studies have assessed the system of modifiable and mediating pathways leading to diabetes mellitus. We aimed to develop a pathway model for Diabetes Risk with modifiable Lifestyle Risk factors as the start point and Physiolo...

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Main Authors: Ho, Lynn Yi-Ching, Lee, Vivian Shu Yi, Ho, Ringo Moon-Ho, Lin, Gladis Jing, Thumboo, Julian
Other Authors: School of Social Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/154032
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1540322023-03-05T15:34:30Z Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk Ho, Lynn Yi-Ching Lee, Vivian Shu Yi Ho, Ringo Moon-Ho Lin, Gladis Jing Thumboo, Julian School of Social Sciences Social sciences::General Diabetes Risk Factors Modifiable risk factors are of interest for chronic disease prevention. Few studies have assessed the system of modifiable and mediating pathways leading to diabetes mellitus. We aimed to develop a pathway model for Diabetes Risk with modifiable Lifestyle Risk factors as the start point and Physiological Load as the mediator. As there are no standardised risk thresholds for lifestyle behaviour, we derived a weighted composite for Lifestyle Risk. Physiological Load was based on an index using clinical thresholds. Sociodemographics are non-modifiable risk factors and were specified as covariates. We used structural equation modeling to test the model, first using 2014/2015 data from the Indonesian Family Life Survey. Next, we fitted a smaller model with longitudinal data (2007/2008 to 2014/2015), given limited earlier data. Both models showed the indirect effects of Lifestyle Risk on Diabetes Risk via the mediator of Physiological Load, whereas the direct effect was only supported in the cross-sectional analysis. Specifying Lifestyle Risk as an observable, composite variable incorporates the cumulative effect of risk behaviour and differentiates this study from previous studies assessing it as a latent construct. The parsimonious model groups the multifarious risk factors and illustrates modifiable pathways that could be applied in chronic disease prevention efforts. National Medical Research Council (NMRC) Published version Y.-C.L.H and V.S.Y.L are funded by a grant, NMRC/CG/C027/2017. 2022-06-08T01:13:11Z 2022-06-08T01:13:11Z 2021 Journal Article Ho, L. Y., Lee, V. S. Y., Ho, R. M., Lin, G. J. & Thumboo, J. (2021). Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk. International Journal of Environmental Research and Public Health, 18(20), 10907-. https://dx.doi.org/10.3390/ijerph182010907 1660-4601 https://hdl.handle.net/10356/154032 10.3390/ijerph182010907 34682644 2-s2.0-85117010970 20 18 10907 en NMRC/CG/C027/2017 International Journal of Environmental Research and Public Health © 2021 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Social sciences::General
Diabetes
Risk Factors
spellingShingle Social sciences::General
Diabetes
Risk Factors
Ho, Lynn Yi-Ching
Lee, Vivian Shu Yi
Ho, Ringo Moon-Ho
Lin, Gladis Jing
Thumboo, Julian
Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
description Modifiable risk factors are of interest for chronic disease prevention. Few studies have assessed the system of modifiable and mediating pathways leading to diabetes mellitus. We aimed to develop a pathway model for Diabetes Risk with modifiable Lifestyle Risk factors as the start point and Physiological Load as the mediator. As there are no standardised risk thresholds for lifestyle behaviour, we derived a weighted composite for Lifestyle Risk. Physiological Load was based on an index using clinical thresholds. Sociodemographics are non-modifiable risk factors and were specified as covariates. We used structural equation modeling to test the model, first using 2014/2015 data from the Indonesian Family Life Survey. Next, we fitted a smaller model with longitudinal data (2007/2008 to 2014/2015), given limited earlier data. Both models showed the indirect effects of Lifestyle Risk on Diabetes Risk via the mediator of Physiological Load, whereas the direct effect was only supported in the cross-sectional analysis. Specifying Lifestyle Risk as an observable, composite variable incorporates the cumulative effect of risk behaviour and differentiates this study from previous studies assessing it as a latent construct. The parsimonious model groups the multifarious risk factors and illustrates modifiable pathways that could be applied in chronic disease prevention efforts.
author2 School of Social Sciences
author_facet School of Social Sciences
Ho, Lynn Yi-Ching
Lee, Vivian Shu Yi
Ho, Ringo Moon-Ho
Lin, Gladis Jing
Thumboo, Julian
format Article
author Ho, Lynn Yi-Ching
Lee, Vivian Shu Yi
Ho, Ringo Moon-Ho
Lin, Gladis Jing
Thumboo, Julian
author_sort Ho, Lynn Yi-Ching
title Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
title_short Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
title_full Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
title_fullStr Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
title_full_unstemmed Towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
title_sort towards a parsimonious pathway model of modifiable and mediating risk factors leading to diabetes risk
publishDate 2022
url https://hdl.handle.net/10356/154032
_version_ 1759857356607324160