Cyclic di-AMP oversight of counter-ion osmolyte pools impacts intrinsic cefuroxime resistance in Lactococcus lactis

• Main Authors: Pham, Huong Thi, Shi, Wen, Xiang, Yuwei, Foo, Su Yi, Plan, Manuel R., Courtin, Pascal, Chapot-Chartier, Marie-Pierre, Smid, Eddy J., Liang, Zhao-Xun, Marcellin, Esteban, Turner, Mark S.
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Cyclic di-AMP; Antibiotic Resistance
• Online Access: https://hdl.handle.net/10356/154055
• Institution: Nanyang Technological University

The broadly conserved cyclic di-AMP (c-di-AMP) is a conditionally essential bacterial second messenger. The pool of c-di-AMP is fine-tuned through diadenylate cyclase and phosphodiesterase activities, and direct binding of c-di-AMP to proteins and riboswitches allows the regulation of a broad spectr...