Structural basis and function of the N terminus of SARS-CoV-2 nonstructural protein 1

• Main Authors: Zhao, Kaitao, Ke, Zunhui, Hu, Hongbing, Liu, Yahui, Li, Aixin, Hua, Rong, Guo, Fangteng, Xiao, Junfeng, Zhang, Yu, Duan, Ling, Yan, Xin-Fu, Gao, Yong-Gui, Liu, Bing, Xia, Yuchen, Li, Yan
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; N Terminus; SARS-CoV-2
• Online Access: https://hdl.handle.net/10356/154058
• Institution: Nanyang Technological University

Nonstructural protein 1 (Nsp1) of severe acute respiratory syndrome coronaviruses (SARS-CoVs) is an important pathogenic factor that inhibits host protein translation by means of its C terminus. However, its N-terminal function remains elusive. Here, we determined the crystal structure of the N term...