In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers

The purpose of this study is to investigate the change in chemical structures of biopolymers PLGA 80:20 and PLLA during thermal and oxidative degradation by the means of in-situ Raman spectroscopy monitoring. Both isothermal and non-isothermal testing, with or with little presence of oxygen...

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Main Author: Tan, Jia Hui.
Other Authors: Loo Say Chye Joachim
Format: Final Year Project
Language:English
Published: 2009
Subjects:
Online Access:http://hdl.handle.net/10356/15446
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-154462023-03-04T15:36:10Z In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers Tan, Jia Hui. Loo Say Chye Joachim School of Materials Science and Engineering A*STAR Institute of Chemical & Engineering Sciences DRNTU::Engineering DRNTU::Engineering::Materials The purpose of this study is to investigate the change in chemical structures of biopolymers PLGA 80:20 and PLLA during thermal and oxidative degradation by the means of in-situ Raman spectroscopy monitoring. Both isothermal and non-isothermal testing, with or with little presence of oxygen, will be conducted to monitor the changes in chemical configuration of biopolymers with respect to the increasing degradation temperature or time. It was found that the number of carbonyl groups and vas CH3 and vCH stretching regions decreased with increasing degradation. The former was due to degradation of carbonyl group while the latter was due to random chain scission. The COC regions (1092 v/cm-1, 1179 v/cm-1 and 1216 v/cm-1) were very stable throughout the whole degradation process. Interestingly, the CCO region (398 v/cm-1 to 441 v/cm-1) increased with prolonged degradation time. This was due to the increase in degree of crystallinilty (DOC) of the biopolymers. This increase could be further confirmed by the analysis done by TGA. Bachelor of Engineering (Materials Engineering) 2009-04-30T08:14:48Z 2009-04-30T08:14:48Z 2009 2009 Final Year Project (FYP) http://hdl.handle.net/10356/15446 en Nanyang Technological University 68 p. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic DRNTU::Engineering
DRNTU::Engineering::Materials
spellingShingle DRNTU::Engineering
DRNTU::Engineering::Materials
Tan, Jia Hui.
In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers
description The purpose of this study is to investigate the change in chemical structures of biopolymers PLGA 80:20 and PLLA during thermal and oxidative degradation by the means of in-situ Raman spectroscopy monitoring. Both isothermal and non-isothermal testing, with or with little presence of oxygen, will be conducted to monitor the changes in chemical configuration of biopolymers with respect to the increasing degradation temperature or time. It was found that the number of carbonyl groups and vas CH3 and vCH stretching regions decreased with increasing degradation. The former was due to degradation of carbonyl group while the latter was due to random chain scission. The COC regions (1092 v/cm-1, 1179 v/cm-1 and 1216 v/cm-1) were very stable throughout the whole degradation process. Interestingly, the CCO region (398 v/cm-1 to 441 v/cm-1) increased with prolonged degradation time. This was due to the increase in degree of crystallinilty (DOC) of the biopolymers. This increase could be further confirmed by the analysis done by TGA.
author2 Loo Say Chye Joachim
author_facet Loo Say Chye Joachim
Tan, Jia Hui.
format Final Year Project
author Tan, Jia Hui.
author_sort Tan, Jia Hui.
title In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers
title_short In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers
title_full In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers
title_fullStr In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers
title_full_unstemmed In-situ Raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(L-lactide) (PLLA) and poly(lactide-co-glycolide) (PLGA) polymers
title_sort in-situ raman spectroscopy monitoring of the thermal and oxidative accelerated degradation of poly(l-lactide) (plla) and poly(lactide-co-glycolide) (plga) polymers
publishDate 2009
url http://hdl.handle.net/10356/15446
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