Paracrine effect of TAK1 in fibroblasts on the oncogenic potential of adjacent epithelia.

• Main Author: Yeo, Ronne Wee Yeh.
• Other Authors: Tan Nguan Soon
• Format: Final Year Project
• Language: English
• Published: 2009
• Subjects: DRNTU::Science::Biological sciences::Molecular biology
• Online Access: http://hdl.handle.net/10356/15455
• Institution: Nanyang Technological University

Among the different cell types of the stroma, fibroblasts are the key contributors of paracrine signals which govern epithelial homeostasis. Transforming growth factor-beta (TGFβ) is one such signal which exhibits autocrine and paracrine effects. Recent findings have shown that TGFβ signaling in fib...