Combating antimicrobial resistance : novel targets and anti-infectives development

• Main Author: Chew, Alvin Bing Liang
• Other Authors: Luo Dahai
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2022
• Subjects: Science::Biological sciences::Molecular biology; Science::Biological sciences::Microbiology::Drug Resistance
• Online Access: https://hdl.handle.net/10356/154808
• Institution: Nanyang Technological University

Antimicrobial resistance (AMR) is projected to cost 100 trillion USD and 10 million lives yearly by 2050 with the rise of superbugs, overuse of antimicrobials, and a lack of new antibiotics in the pipeline. To combat AMR, new antibiotics are sorely needed. This thesis reports a structural microbiolo...