Hydroalkylation of styrenes with benzylamines by potassium hydride
A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation of styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated by solvothermal treatment of benzylamines with KH at 100 °C to generate deprotonated anionic species, which undergo selective...
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sg-ntu-dr.10356-1548272023-02-28T19:58:24Z Hydroalkylation of styrenes with benzylamines by potassium hydride Pang, Jia Hao Wang, Bin Watanabe, Kohei Takita, Ryo Chiba, Shunsuke School of Physical and Mathematical Sciences Science::Chemistry Alkylation Arylalkenes A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation of styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated by solvothermal treatment of benzylamines with KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation with arylalkenes at 0 °C to ambient temperature to afford 1,3-diarylpropylamines as the major product. Ministry of Education (MOE) Nanyang Technological University Accepted version This work was financially supported by Nanyang Technological University (NTU) and the Singapore Ministry of Education (Academic Research Fund Tier 2: MOE2019-T2-1-089) for S.C. as well as JSPS KAKENHI grant JP19 K06992, and the Naito Foundation for R. T. 2022-01-12T05:17:55Z 2022-01-12T05:17:55Z 2021 Journal Article Pang, J. H., Wang, B., Watanabe, K., Takita, R. & Chiba, S. (2021). Hydroalkylation of styrenes with benzylamines by potassium hydride. Helvetica Chimica Acta, 104(10), e2100120-. https://dx.doi.org/10.1002/hlca.202100120 1522-2675 https://hdl.handle.net/10356/154827 10.1002/hlca.202100120 2-s2.0-85115297946 10 104 e2100120 en MOE2019-T2-1-089 Helvetica Chimica Acta © 2021 Wiley-VHCA AG. All rights reserved. This paper was published in Helvetica Chimica Acta and is made available with permission of Wiley-VHCA AG. application/pdf |
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Science::Chemistry Alkylation Arylalkenes |
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Science::Chemistry Alkylation Arylalkenes Pang, Jia Hao Wang, Bin Watanabe, Kohei Takita, Ryo Chiba, Shunsuke Hydroalkylation of styrenes with benzylamines by potassium hydride |
| description |
A method for the synthesis of 1,3-diarylpropylamines through hydroalkylation of styrenes with benzylamines by potassium hydride has been developed. The protocol is initiated by solvothermal treatment of benzylamines with KH at 100 °C to generate deprotonated anionic species, which undergo selective C-alkylation with arylalkenes at 0 °C to ambient temperature to afford 1,3-diarylpropylamines as the major product. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Pang, Jia Hao Wang, Bin Watanabe, Kohei Takita, Ryo Chiba, Shunsuke |
| format |
Article |
| author |
Pang, Jia Hao Wang, Bin Watanabe, Kohei Takita, Ryo Chiba, Shunsuke |
| author_sort |
Pang, Jia Hao |
| title |
Hydroalkylation of styrenes with benzylamines by potassium hydride |
| title_short |
Hydroalkylation of styrenes with benzylamines by potassium hydride |
| title_full |
Hydroalkylation of styrenes with benzylamines by potassium hydride |
| title_fullStr |
Hydroalkylation of styrenes with benzylamines by potassium hydride |
| title_full_unstemmed |
Hydroalkylation of styrenes with benzylamines by potassium hydride |
| title_sort |
hydroalkylation of styrenes with benzylamines by potassium hydride |
| publishDate |
2022 |
| url |
https://hdl.handle.net/10356/154827 |
| _version_ |
1759857839432531968 |