Synthesis of fasicularin

The synthesis of a tricyclic marine alkaloid, fasicularin, was accomplished. Stereoselective synthesis of the aza-spirocyclic BC-ring precursor and ensuing construction of the A-ring with stereocontrolled installation of the C2 hexyl group feature prominently in the synthesis.

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Main Authors: Kaga, Atsushi, Tnay, Ya Lin, Chiba, Shunsuke
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2022
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Online Access:https://hdl.handle.net/10356/154863
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Institution: Nanyang Technological University
Language: English
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spelling sg-ntu-dr.10356-1548632023-02-28T19:59:10Z Synthesis of fasicularin Kaga, Atsushi Tnay, Ya Lin Chiba, Shunsuke School of Physical and Mathematical Sciences Science::Chemistry Transfer Reactions Aziridines The synthesis of a tricyclic marine alkaloid, fasicularin, was accomplished. Stereoselective synthesis of the aza-spirocyclic BC-ring precursor and ensuing construction of the A-ring with stereocontrolled installation of the C2 hexyl group feature prominently in the synthesis. Ministry of Education (MOE) Nanyang Technological University Accepted version This work was supported by funding from Nanyang Technological University and the Singapore Ministry of Education and Singapore Ministry of Education (Academic Research Fund Tier 1: RG4/13). 2022-01-17T02:31:35Z 2022-01-17T02:31:35Z 2016 Journal Article Kaga, A., Tnay, Y. L. & Chiba, S. (2016). Synthesis of fasicularin. Organic Letters, 18(14), 3506-3508. https://dx.doi.org/10.1021/acs.orglett.6b01669 1523-7060 https://hdl.handle.net/10356/154863 10.1021/acs.orglett.6b01669 27355342 2-s2.0-84978695883 14 18 3506 3508 en RG4/13 Organic Letters This document is the Accepted Manuscript version of a Published Work that appeared in final form in Organic Letters, copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see https://doi.org/10.1021/acs.orglett.6b01669. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Science::Chemistry
Transfer Reactions
Aziridines
spellingShingle Science::Chemistry
Transfer Reactions
Aziridines
Kaga, Atsushi
Tnay, Ya Lin
Chiba, Shunsuke
Synthesis of fasicularin
description The synthesis of a tricyclic marine alkaloid, fasicularin, was accomplished. Stereoselective synthesis of the aza-spirocyclic BC-ring precursor and ensuing construction of the A-ring with stereocontrolled installation of the C2 hexyl group feature prominently in the synthesis.
author2 School of Physical and Mathematical Sciences
author_facet School of Physical and Mathematical Sciences
Kaga, Atsushi
Tnay, Ya Lin
Chiba, Shunsuke
format Article
author Kaga, Atsushi
Tnay, Ya Lin
Chiba, Shunsuke
author_sort Kaga, Atsushi
title Synthesis of fasicularin
title_short Synthesis of fasicularin
title_full Synthesis of fasicularin
title_fullStr Synthesis of fasicularin
title_full_unstemmed Synthesis of fasicularin
title_sort synthesis of fasicularin
publishDate 2022
url https://hdl.handle.net/10356/154863
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