Adventitial injection delivery of nano-encapsulated sirolimus (Nanolimus) to injury-induced porcine femoral vessels to reduce luminal restenosis

• Main Authors: Ang, Hui Ying, Xiong, Gordon Minru, Chaw, Su Yin, Phua, Jie Liang, Ng, Jaryl Chen Koon, Wong, Philip En Hou, Venkatraman, Subbu, Chong, Tze Tec, Huang, Yingying
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Materials; Peripheral Artery Disease; Vascular Restenosis
• Online Access: https://hdl.handle.net/10356/154898
• Institution: Nanyang Technological University

Endovascular therapy in peripheral intervention has grown exponentially in the past decade, but the issue of high restenosis rates in lower extremity arteries still persist. While drug-coated balloons (DCB) have been the device of choice, recent controversary regarding the long-term safety of paclit...