Human ACE2 receptor polymorphisms and altered susceptibility to SARS-CoV-2

• Main Authors: Suryamohan, Kushal, Diwanji, Devan, Stawiski, Eric W., Gupta, Ravi, Miersch, Shane, Liu, Jiang, Chen, Chao, Jiang, Ying-Ping, Fellouse, Frederic A., Sathirapongsasuti, J. Fah, Albers, Patrick K., Deepak, Tanneeru, Saberianfar, Reza, Ratan, Aakrosh, Washburn, Gavin, Mis, Monika, Santhosh, Devi, Somasekar, Sneha, Hiranjith, G. H., Vargas, Derek, Mohan, Sangeetha, Phalke, Sameer, Kuriakose, Boney, Antony, Aju, Ustav, Mart, Schuster, Stephan Christoph, Sidhu, Sachdev, Junutula, Jagath R., Jura, Natalia, Seshagiri, Somasekar
• Other Authors: Singapore Centre for Environmental Life Sciences and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Environmental engineering; Spike Protein; Structural-Analysis
• Online Access: https://hdl.handle.net/10356/154952
• Institution: Nanyang Technological University

COVID-19 is a respiratory illness caused by a novel coronavirus called SARS-CoV-2. The viral spike (S) protein engages the human angiotensin-converting enzyme 2 (ACE2) receptor to invade host cells with ~10-15-fold higher affinity compared to SARS-CoV S-protein, making it highly infectious. Here, we...