Assembly of multicyclic isoquinoline scaffolds from pyridines : formal total synthesis of fredericamycin A

• Main Authors: Wang, Fang-Xin, Yan, Jia-Lei, Liu, Zhixin, Zhu, Tingshun, Liu, Yingguo, Ren, Shi-Chao, Lv, Wen-Xin, Jin, Zhichao, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Carbonyl Compounds; Scaffolds
• Online Access: https://hdl.handle.net/10356/155060
• Institution: Nanyang Technological University

The construction of an isoquinoline skeleton typically starts with benzene derivatives as substrates with the assistance of acids or transition metals. Disclosed here is a concise approach to prepare isoquinoline analogues by starting with pyridines to react with β-ethoxy α,β-unsaturated carbonyl co...