Fibroblast growth factor 21 mediates the associations between exercise, aging, and glucose regulation

• Main Authors: Lee, Shuen Yee, Burns, Stephen F., Ng, Kenneth K. C., Stensel, David J., Zhong, Liang, Tan, Frankie H. Y., Chia, Kar Ling, Fam, Kai Deng, Yap, Margaret M. C., Yeo, Kwee Poo, Yap, Eric Peng Huat, Lim, Chin Leong
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Adiponectin; Insulin
• Online Access: https://hdl.handle.net/10356/155075
• Institution: Nanyang Technological University

Aging increases the prevalence of glucose intolerance, but exercise improves glucose homeostasis. The fibroblast growth factor 21 (FGF21)-adiponectin axis helps regulate glucose metabolism. However, the role of FGF21 in mediating glucose metabolism with aging and exercise remains unknown.