Continuous crystallization as a downstream processing step of pharmaceutical proteins : a review

• المؤلفون الرئيسيون: Pu, Siyu, Hadinoto, Kunn
• مؤلفون آخرون: School of Chemical and Biomedical Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Engineering::Bioengineering; Biopharmaceuticals; Biologics
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155138

Continuous crystallization has been proposed as the downstream processing step for the purification of pharmaceutical proteins aimed at alleviating the manufacturing bottleneck caused by the limitations of chromatography-based operations at high upstream production titers. Herein we reviewed the cur...