Potent-by-design : amino acids mimicking porous nanotherapeutics with intrinsic anticancer targeting properties

• Main Authors: Wu, Zhuoran, Lim, Hong Kit, Tan, Shao Jie, Gautam, Archana, Hou, Han Wei, Ng, Kee Woei, Tan, Nguan Soon, Tay, Chor Yong
• Other Authors: School of Materials Science and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Engineering::Materials; Cancer Targeting; Large Neutral Amino Acid Transporter
• Online Access: https://hdl.handle.net/10356/155259
• Institution: Nanyang Technological University

Exogenous sources of amino acids are essential nutrients to fuel cancer growth. Here, the increased demand for amino acid displayed by cancer cells is unconventionally exploited as a design principle to replete cancer cells with apoptosis inducing nanoscopic porous amino acid mimics (Nano-PAAM). A s...