Phosphatase POPX2 interferes with cell cycle by interacting with Chk1

• Main Authors: Kim, Pu Rum, Koon, Yen Ling, Lee, Raphael Tze Chuen, Azizan, Farouq, Koh, Dylan Hong Zheng, Chiam, Keng-Hwee, Koh, Cheng-Gee
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Protein–Protein Interactions; Partner of PIX 2 Phosphatase
• Online Access: https://hdl.handle.net/10356/155312
• Institution: Nanyang Technological University

Protein-protein interaction network analysis plays critical roles in predicting the functions of target proteins. In this study, we used a combination of SILAC-MS proteomics and bioinformatic approaches to identify Checkpoint Kinase 1 (Chk1) as a possible POPX2 phosphatase interacting protein. POPX2...