Long-term oxytetracycline exposure potentially alters brain thyroid hormone and serotonin homeostasis in zebrafish

• Main Authors: Li, Jiawei, Dong, Ting, Keerthisinghe, Tharushi Prabha, Chen, Hao, Li, Ming, Chu, Wenqing, Yang, Jingfeng, Hu, Zongfu, Snyder, Shane Allen, Dong, Wu, Fang, Mingliang
• Other Authors: School of Civil and Environmental Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Civil engineering; Oxytetracycline; Zebrafish
• Online Access: https://hdl.handle.net/10356/155341
• Institution: Nanyang Technological University

The impact of oxytetracycline (OTC) exposure in water on the fish still remains unclear. We hypothesized OTC exposure could alter fish gut microbiome and affect thyroid hormone and serotonin homeostasis in the brain via "chemical-gut-brain" axis. Here, ∼2-month-old juvenile zebrafish (Dani...