Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data

• المؤلفون الرئيسيون: Liu, Hui, Zhang, Fan, Mishra, Shital Kumar, Zhou, Shuigeng, Zheng, Jie
• مؤلفون آخرون: School of Computer Science and Engineering
• التنسيق: مقال
• اللغة: English
• منشور في: 2022
• الموضوعات: Engineering::Computer science and engineering; Signaling Pathways; Cellular Signaling Networks; Hybrid Modeling
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155401

Modeling of signaling pathways is crucial for understanding and predicting cellular responses to drug treatments. However, canonical signaling pathways curated from literature are seldom context-specific and thus can hardly predict cell type-specific response to external perturbations; purely data-d...