Knowledge-guided fuzzy logic modeling to infer cellular signaling networks from proteomic data

• Main Authors: Liu, Hui, Zhang, Fan, Mishra, Shital Kumar, Zhou, Shuigeng, Zheng, Jie
• Other Authors: School of Computer Science and Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Computer science and engineering; Signaling Pathways; Cellular Signaling Networks; Hybrid Modeling
• Online Access: https://hdl.handle.net/10356/155401
• Institution: Nanyang Technological University

Modeling of signaling pathways is crucial for understanding and predicting cellular responses to drug treatments. However, canonical signaling pathways curated from literature are seldom context-specific and thus can hardly predict cell type-specific response to external perturbations; purely data-d...