Chemoresistance and metastasis in colorectal cancer
Despite major advancements in the understanding of tumor biology and the field of cancer therapeutics in the past decade, drug resistance and metastasis still pose a constant problem for cancer patients that calls for urgent attention and research. In the current thesis, we investigated mechanisms i...
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2022
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sg-ntu-dr.10356-1554182023-02-28T18:33:29Z Chemoresistance and metastasis in colorectal cancer Wong, Stephen Qi Rong Peter Droge School of Biological Sciences Genome Institute of Singapore Ramanuj Dasgupta PDroge@ntu.edu.sg, dasguptar@gis.a-star.edu.sg Science::Biological sciences::Molecular biology Science::Biological sciences::Genetics Science::Biological sciences::Biochemistry Despite major advancements in the understanding of tumor biology and the field of cancer therapeutics in the past decade, drug resistance and metastasis still pose a constant problem for cancer patients that calls for urgent attention and research. In the current thesis, we investigated mechanisms in which colorectal cancer gain resistance to commonly used cytotoxic agents oxaliplatin and irinotecan, making them more metastatic after the course of treatment. The first part of my thesis will describe a study where we observed increased PAI-1 expression in HCT116 treated with ten cycles of clinically relevant doses of oxaliplatin, and demonstrated a functional role of the protein in promoting oxaliplatin resistance and spontaneous metastasis in mice. In a second study, we employed the use of clinically relevant PDX models of CRC to validate the role of HMGA2, an oncofetal protein, in causing sensitivity to irinotecan treatment. Doctor of Philosophy 2022-02-23T02:24:58Z 2022-02-23T02:24:58Z 2022 Thesis-Doctor of Philosophy Wong, S. Q. R. (2022). Chemoresistance and metastasis in colorectal cancer. Doctoral thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/155418 https://hdl.handle.net/10356/155418 10.32657/10356/155418 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University |
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Science::Biological sciences::Molecular biology Science::Biological sciences::Genetics Science::Biological sciences::Biochemistry Wong, Stephen Qi Rong Chemoresistance and metastasis in colorectal cancer |
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Despite major advancements in the understanding of tumor biology and the field of cancer therapeutics in the past decade, drug resistance and metastasis still pose a constant problem for cancer patients that calls for urgent attention and research. In the current thesis, we investigated mechanisms in which colorectal cancer gain resistance to commonly used cytotoxic agents oxaliplatin and irinotecan, making them more metastatic after the course of treatment.
The first part of my thesis will describe a study where we observed increased PAI-1 expression in HCT116 treated with ten cycles of clinically relevant doses of oxaliplatin, and demonstrated a functional role of the protein in promoting oxaliplatin resistance and spontaneous metastasis in mice. In a second study, we employed the use of clinically relevant PDX models of CRC to validate the role of HMGA2, an oncofetal protein, in causing sensitivity to irinotecan treatment. |
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Peter Droge |
author_facet |
Peter Droge Wong, Stephen Qi Rong |
format |
Thesis-Doctor of Philosophy |
author |
Wong, Stephen Qi Rong |
author_sort |
Wong, Stephen Qi Rong |
title |
Chemoresistance and metastasis in colorectal cancer |
title_short |
Chemoresistance and metastasis in colorectal cancer |
title_full |
Chemoresistance and metastasis in colorectal cancer |
title_fullStr |
Chemoresistance and metastasis in colorectal cancer |
title_full_unstemmed |
Chemoresistance and metastasis in colorectal cancer |
title_sort |
chemoresistance and metastasis in colorectal cancer |
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Nanyang Technological University |
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2022 |
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https://hdl.handle.net/10356/155418 |
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1759853625738264576 |