Membrane cholesterol modulates oligomeric status and peptide-membrane interaction of severe acute respiratory syndrome coronavirus fusion peptide

• Main Authors: Meher, Geetanjali, Bhattacharjya, Surajit, Chakraborty, Hirak
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Severe Acute Respiratory Syndrome; Cell Membrane
• Online Access: https://hdl.handle.net/10356/155451
• Institution: Nanyang Technological University

The N-terminal fusion peptide (residues 770-788) of an S2 glycoprotein of the severe acute respiratory syndrome coronavirus (SARS-CoV), exposed upon receptor binding, is crucial for virus entry into the host cell. The fusion peptide alters the membrane organization and dynamics of the host membrane...