Biallelic NF1 inactivation in high grade serous ovarian cancers from patients with neurofibromatosis type 1

• Main Authors: Courtney, Eliza, Chan, Sock Hoai, Li, Shao Tzu, Ishak, Diana, Merchant, Khurshid, Shaw, Tarryn, Chay, Wen Yee, Chin, Felicia Hui Xian, Wong, Wai Loong, Wong, Adele, Ngeow, Joanne
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Neurofbromatosis; Neurofbromin
• Online Access: https://hdl.handle.net/10356/155620
• Institution: Nanyang Technological University

Neurofibromatosis type 1 (NF1) is a multisystem disorder caused by germline heterozygous NF1 loss-of-function variants. The NF1 gene encodes neurofibromin, a RAS GTPase-activating protein, which functions by down-regulating RAS/RAF/MAPK-signalling pathways. Somatic NF1 aberrations frequently occur i...