Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration

In the pharmaceutical industry, biocatalysts are mainly utilized for synthesizing Active Pharmaceutical Ingredients (API’s) and their intermediates. API purification is one of the vital steps in pharmaceutical downstream processing as the product purity affects the market value of the drug. Membrane...

Full description

Saved in:
Bibliographic Details
Main Author: Kapavarapu, Mohanish Sai Raghavendra Sridhar
Other Authors: Chew Jia Wei
Format: Thesis-Master by Research
Language:English
Published: Nanyang Technological University 2022
Subjects:
Online Access:https://hdl.handle.net/10356/155634
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-155634
record_format dspace
spelling sg-ntu-dr.10356-1556342022-04-04T03:16:53Z Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration Kapavarapu, Mohanish Sai Raghavendra Sridhar Chew Jia Wei School of Chemical and Biomedical Engineering JChew@ntu.edu.sg Engineering::Chemical engineering::Processes and operations In the pharmaceutical industry, biocatalysts are mainly utilized for synthesizing Active Pharmaceutical Ingredients (API’s) and their intermediates. API purification is one of the vital steps in pharmaceutical downstream processing as the product purity affects the market value of the drug. Membrane separation is a cost-effective and sustainable separation process mainly preferred due to its lower energy consumption. However, there is not any specific analysis that deals with the economics of a membrane separation unit specific to biocatalyst separation in pharmaceutical industry. So, this study presents insights into the economics of an ultrafiltration (UF) unit for various operating modes and stage configurations in biocatalyst separation. It was estimated from the current study that a capital expenditure of $1.35 million and an annual operating expenditure of $85 thousand are required to set up a new UF unit to obtain 640 million litres of permeate annually for input of 100,000 L/hr of feed. The cost components of the UF unit at constant flux mode, constant transmembrane pressure (TMP) mode and four different stage configurations were assessed. The analysis on the mode of operation to obtain the desired recovery of 80% suggests operating the unit at a constant flux mode (capital of $1.35 million and annual operating cost of $85.60 thousand at 55 LMH) rather than constant TMP (capital of $2.34 million and annual operating cost of $124.25 thousand at 0.25 MPa) mode due to higher area requirement and annual membrane replacement costs in the latter case. The analysis of the stage configuration shows the variation of cost expenditures with additional stages to improve recovery and purity. When compared to the single-stage configuration, the costs nearly doubled (capital of $2.82 million and annual operating cost of $145.77 thousand) in the three-stage configuration to operate the unit with the highest purity and recovery. This study can be used to understand the variations in expenditure to choose the right operating values and make decisions during industrial design and planning. Master of Engineering 2022-03-09T02:42:59Z 2022-03-09T02:42:59Z 2021 Thesis-Master by Research Kapavarapu, M. S. R. S. (2021). Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration. Master's thesis, Nanyang Technological University, Singapore. https://hdl.handle.net/10356/155634 https://hdl.handle.net/10356/155634 10.32657/10356/155634 en This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License (CC BY-NC 4.0). application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Chemical engineering::Processes and operations
spellingShingle Engineering::Chemical engineering::Processes and operations
Kapavarapu, Mohanish Sai Raghavendra Sridhar
Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
description In the pharmaceutical industry, biocatalysts are mainly utilized for synthesizing Active Pharmaceutical Ingredients (API’s) and their intermediates. API purification is one of the vital steps in pharmaceutical downstream processing as the product purity affects the market value of the drug. Membrane separation is a cost-effective and sustainable separation process mainly preferred due to its lower energy consumption. However, there is not any specific analysis that deals with the economics of a membrane separation unit specific to biocatalyst separation in pharmaceutical industry. So, this study presents insights into the economics of an ultrafiltration (UF) unit for various operating modes and stage configurations in biocatalyst separation. It was estimated from the current study that a capital expenditure of $1.35 million and an annual operating expenditure of $85 thousand are required to set up a new UF unit to obtain 640 million litres of permeate annually for input of 100,000 L/hr of feed. The cost components of the UF unit at constant flux mode, constant transmembrane pressure (TMP) mode and four different stage configurations were assessed. The analysis on the mode of operation to obtain the desired recovery of 80% suggests operating the unit at a constant flux mode (capital of $1.35 million and annual operating cost of $85.60 thousand at 55 LMH) rather than constant TMP (capital of $2.34 million and annual operating cost of $124.25 thousand at 0.25 MPa) mode due to higher area requirement and annual membrane replacement costs in the latter case. The analysis of the stage configuration shows the variation of cost expenditures with additional stages to improve recovery and purity. When compared to the single-stage configuration, the costs nearly doubled (capital of $2.82 million and annual operating cost of $145.77 thousand) in the three-stage configuration to operate the unit with the highest purity and recovery. This study can be used to understand the variations in expenditure to choose the right operating values and make decisions during industrial design and planning.
author2 Chew Jia Wei
author_facet Chew Jia Wei
Kapavarapu, Mohanish Sai Raghavendra Sridhar
format Thesis-Master by Research
author Kapavarapu, Mohanish Sai Raghavendra Sridhar
author_sort Kapavarapu, Mohanish Sai Raghavendra Sridhar
title Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
title_short Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
title_full Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
title_fullStr Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
title_full_unstemmed Economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
title_sort economic analysis of membrane-based separation of biocatalyst : mode of operation and stage configuration
publisher Nanyang Technological University
publishDate 2022
url https://hdl.handle.net/10356/155634
_version_ 1729789473685766144