Modification of triphenylphosphonium lipophilic cations for mitochondrial delivery

• Main Author: Ong, How Chee
• Other Authors: Leong Weng Kee
• Format: Thesis-Doctor of Philosophy
• Language: English
• Published: Nanyang Technological University 2022
• Subjects: Science::Chemistry::Inorganic chemistry; Science::Chemistry::Biochemistry
• Online Access: https://hdl.handle.net/10356/155725
• Institution: Nanyang Technological University

Triphenylphosphonium (TPP+) moieties, when conjugated to a molecule of interest, results in greater mitochondrial accumulation relative to the unconjugated cargo. However, while TPP+ moieties are known to be effective at conferring mitochondrial-targeting abilities to molecules, modifications to the...