Modification of triphenylphosphonium lipophilic cations for mitochondrial delivery

• المؤلف الرئيسي: Ong, How Chee
• مؤلفون آخرون: Leong Weng Kee
• التنسيق: Thesis-Doctor of Philosophy
• اللغة: English
• منشور في: Nanyang Technological University 2022
• الموضوعات: Science::Chemistry::Inorganic chemistry; Science::Chemistry::Biochemistry
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/155725
• المؤسسة: Nanyang Technological University

Triphenylphosphonium (TPP+) moieties, when conjugated to a molecule of interest, results in greater mitochondrial accumulation relative to the unconjugated cargo. However, while TPP+ moieties are known to be effective at conferring mitochondrial-targeting abilities to molecules, modifications to the...