Missing-linker-assisted artesunate delivery by metal-organic frameworks for synergistic cancer treatment

• Main Authors: Wang, Dongdong, He, Isabel Wenjia, Liu, Jiawei, Jana, Deblin, Wu, Yinglong, Zhang, Xiaodong, Qian, Cheng, Guo, Yi, Chen, Xiaokai, Bindra, Anivind Kaur, Zhao, Yanli
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Chemistry; Artesunate; Metal–Organic Framework
• Online Access: https://hdl.handle.net/10356/155942
• Institution: Nanyang Technological University

Clinical translation of artesunate (ATS) as a potent antitumor drug has been obstructed by its rapid degradation and low bioavailability. Herein, we report the development of ATS nanomedicine through the self-assembly with Mn[Co(CN)6]2/31/3 metal-organic frameworks (MOFs) having hidden missing link...