Developing a normative database for retinal perfusion using optical coherence tomography angiography

Visualizing and characterizing microvascular abnormalities with optical coherence tomography angiography (OCTA) has deepened our understanding of ocular diseases, such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Two types of microvascular defects can be detected by OCTA:...

Full description

Saved in:
Bibliographic Details
Main Authors: Tan, Bingyao, Sim, Yin Ci, Chua, Jacqueline, Yusufi, Dheo, Wong, Damon Wing Kee, Yow, Ai Ping, Chin, Calvin, Tan, Anna C. S., Sng, Chelvin Cheryl Agnes, Agrawal, Rupesh, Gopal, Lekha, Sim, Ralene, Tan, Gavin, Lamoureux, Ecosse, Schmetterer, Leopold
Other Authors: School of Chemical and Biomedical Engineering
Format: Article
Language:English
Published: 2022
Subjects:
Online Access:https://hdl.handle.net/10356/156182
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
id sg-ntu-dr.10356-156182
record_format dspace
spelling sg-ntu-dr.10356-1561822022-04-11T02:57:15Z Developing a normative database for retinal perfusion using optical coherence tomography angiography Tan, Bingyao Sim, Yin Ci Chua, Jacqueline Yusufi, Dheo Wong, Damon Wing Kee Yow, Ai Ping Chin, Calvin Tan, Anna C. S. Sng, Chelvin Cheryl Agnes Agrawal, Rupesh Gopal, Lekha Sim, Ralene Tan, Gavin Lamoureux, Ecosse Schmetterer, Leopold School of Chemical and Biomedical Engineering Lee Kong Chian School of Medicine (LKCMedicine) Institute for Digital Molecular Analytics and Science (IDMxS) NTU Institute for Health Technologies SERI-NTU Advanced Ocular Engineering (STANCE) Engineering::General Science::Medicine::Optical instruments Optical Tomography Age-Related Macular Degeneration Visualizing and characterizing microvascular abnormalities with optical coherence tomography angiography (OCTA) has deepened our understanding of ocular diseases, such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Two types of microvascular defects can be detected by OCTA: focal decrease because of localized absence and collapse of retinal capillaries, which is referred to as the non-perfusion area in OCTA, and diffuse perfusion decrease usually detected by comparing with healthy case-control groups. Wider OCTA allows for insights into peripheral retinal vascularity, but the heterogeneous perfusion distribution from the macula, parapapillary area to periphery hurdles the quantitative assessment. A normative database for OCTA could estimate how much individual's data deviate from the normal range, and where the deviations locate. Here, we acquired OCTA images using a swept-source OCT system and a 12×12 mm protocol in healthy subjects. We automatically segmented the large blood vessels with U-Net, corrected for anatomical factors such as the relative position of fovea and disc, and segmented the capillaries by a moving window scheme. A total of 195 eyes were included and divided into 4 age groups: < 30 (n=24) years old, 30-49 (n=28) years old, 50-69 (n=109) years old and >69 (n=34) years old. This provides an age-dependent normative database for characterizing retinal perfusion abnormalities in 12×12 mm OCTA images. The usefulness of the normative database was tested on two pathological groups: one with diabetic retinopathy; the other with glaucoma. Ministry of Health (MOH) National Medical Research Council (NMRC) Published version National Medical Research Council (NMRC/CG/C010A/2017_SERI, NMRC/OFIRG/0048/2017, NMRC/OFLCG/004c/2018, MOH-000249-00); Duke-NUS Duke-NUS-KP(Coll)/2018/0009A. 2022-04-07T08:54:12Z 2022-04-07T08:54:12Z 2021 Journal Article Tan, B., Sim, Y. C., Chua, J., Yusufi, D., Wong, D. W. K., Yow, A. P., Chin, C., Tan, A. C. S., Sng, C. C. A., Agrawal, R., Gopal, L., Sim, R., Tan, G., Lamoureux, E. & Schmetterer, L. (2021). Developing a normative database for retinal perfusion using optical coherence tomography angiography. Biomedical Optics Express, 12(7), 4032-4045. https://dx.doi.org/10.1364/BOE.423469 2156-7085 https://hdl.handle.net/10356/156182 10.1364/BOE.423469 34457397 2-s2.0-85108252173 7 12 4032 4045 en NMRC/CG/C010A/2017_SERI NMRC/OFIRG/0048/2017 NMRC/OFLCG/004c/2018 MOH-000249-00 Duke-NUS-KP(Coll)/2018/0009A Biomedical Optics Express © 2021 Optical Society of America under the terms of the Open Access Publishing Agreement. Users may use, reuse, and build upon the article, or use the article for text or data mining, so long as such uses are for noncommercial purposes and appropriate attribution is maintained. All other rights are reserved. application/pdf
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::General
Science::Medicine::Optical instruments
Optical Tomography
Age-Related Macular Degeneration
spellingShingle Engineering::General
Science::Medicine::Optical instruments
Optical Tomography
Age-Related Macular Degeneration
Tan, Bingyao
Sim, Yin Ci
Chua, Jacqueline
Yusufi, Dheo
Wong, Damon Wing Kee
Yow, Ai Ping
Chin, Calvin
Tan, Anna C. S.
Sng, Chelvin Cheryl Agnes
Agrawal, Rupesh
Gopal, Lekha
Sim, Ralene
Tan, Gavin
Lamoureux, Ecosse
Schmetterer, Leopold
Developing a normative database for retinal perfusion using optical coherence tomography angiography
description Visualizing and characterizing microvascular abnormalities with optical coherence tomography angiography (OCTA) has deepened our understanding of ocular diseases, such as glaucoma, diabetic retinopathy, and age-related macular degeneration. Two types of microvascular defects can be detected by OCTA: focal decrease because of localized absence and collapse of retinal capillaries, which is referred to as the non-perfusion area in OCTA, and diffuse perfusion decrease usually detected by comparing with healthy case-control groups. Wider OCTA allows for insights into peripheral retinal vascularity, but the heterogeneous perfusion distribution from the macula, parapapillary area to periphery hurdles the quantitative assessment. A normative database for OCTA could estimate how much individual's data deviate from the normal range, and where the deviations locate. Here, we acquired OCTA images using a swept-source OCT system and a 12×12 mm protocol in healthy subjects. We automatically segmented the large blood vessels with U-Net, corrected for anatomical factors such as the relative position of fovea and disc, and segmented the capillaries by a moving window scheme. A total of 195 eyes were included and divided into 4 age groups: < 30 (n=24) years old, 30-49 (n=28) years old, 50-69 (n=109) years old and >69 (n=34) years old. This provides an age-dependent normative database for characterizing retinal perfusion abnormalities in 12×12 mm OCTA images. The usefulness of the normative database was tested on two pathological groups: one with diabetic retinopathy; the other with glaucoma.
author2 School of Chemical and Biomedical Engineering
author_facet School of Chemical and Biomedical Engineering
Tan, Bingyao
Sim, Yin Ci
Chua, Jacqueline
Yusufi, Dheo
Wong, Damon Wing Kee
Yow, Ai Ping
Chin, Calvin
Tan, Anna C. S.
Sng, Chelvin Cheryl Agnes
Agrawal, Rupesh
Gopal, Lekha
Sim, Ralene
Tan, Gavin
Lamoureux, Ecosse
Schmetterer, Leopold
format Article
author Tan, Bingyao
Sim, Yin Ci
Chua, Jacqueline
Yusufi, Dheo
Wong, Damon Wing Kee
Yow, Ai Ping
Chin, Calvin
Tan, Anna C. S.
Sng, Chelvin Cheryl Agnes
Agrawal, Rupesh
Gopal, Lekha
Sim, Ralene
Tan, Gavin
Lamoureux, Ecosse
Schmetterer, Leopold
author_sort Tan, Bingyao
title Developing a normative database for retinal perfusion using optical coherence tomography angiography
title_short Developing a normative database for retinal perfusion using optical coherence tomography angiography
title_full Developing a normative database for retinal perfusion using optical coherence tomography angiography
title_fullStr Developing a normative database for retinal perfusion using optical coherence tomography angiography
title_full_unstemmed Developing a normative database for retinal perfusion using optical coherence tomography angiography
title_sort developing a normative database for retinal perfusion using optical coherence tomography angiography
publishDate 2022
url https://hdl.handle.net/10356/156182
_version_ 1731235719266959360