Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs

Solid lipid microparticles (LMP) are alternatives to polymeric nanoparticles for the encapsulation of hydrophobic components that have poor bioavailability. However, the usual method of fabrication of solid LMP through high pressure homogenization had limitations that caused low encapsulation e...

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Main Author: Low, Celine Yan Jing
Other Authors: Loo Say Chye Joachim
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2022
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Online Access:https://hdl.handle.net/10356/156249
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spelling sg-ntu-dr.10356-1562492022-04-13T08:43:04Z Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs Low, Celine Yan Jing Loo Say Chye Joachim School of Materials Science and Engineering JoachimLoo@ntu.edu.sg Engineering::Materials Solid lipid microparticles (LMP) are alternatives to polymeric nanoparticles for the encapsulation of hydrophobic components that have poor bioavailability. However, the usual method of fabrication of solid LMP through high pressure homogenization had limitations that caused low encapsulation efficiency and potential damage to sensitive molecules. Hence the electrospray technique was investigated as an alternative. In this study, for the fabrication of solid LMP, the electrospray method was explored by varying different parameters such as flow rate and voltage. Scanning Electron Microscopy (SEM) was used to characterize the microparticles. Following the optimization of parameters, curcumin was loaded into the microparticle. Release studies of the curcumin loaded particles in simulated gastrointestinal fluids showed that the encapsulation was able to retard the release of curcumin in simulated gastric fluid (SGF) and release it in the simulated intestinal fluid (SIF). In order to prolong the release of curcumin, the curcumin loaded LMP were further encapsulated into floating particles that can act as a reservoir for LMP. Based on SEM images it was observed that the LMP were mainly localized on the surface of the floating microparticles. Further in vitro release studies on the floating particles need to be conducted to understand the behavior of LMP in the floating particles. Bachelor of Engineering (Materials Engineering) 2022-04-11T07:34:52Z 2022-04-11T07:34:52Z 2022 Final Year Project (FYP) Low, C. Y. J. (2022). Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs. Final Year Project (FYP), Nanyang Technological University, Singapore. https://hdl.handle.net/10356/156249 https://hdl.handle.net/10356/156249 en application/pdf Nanyang Technological University
institution Nanyang Technological University
building NTU Library
continent Asia
country Singapore
Singapore
content_provider NTU Library
collection DR-NTU
language English
topic Engineering::Materials
spellingShingle Engineering::Materials
Low, Celine Yan Jing
Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
description Solid lipid microparticles (LMP) are alternatives to polymeric nanoparticles for the encapsulation of hydrophobic components that have poor bioavailability. However, the usual method of fabrication of solid LMP through high pressure homogenization had limitations that caused low encapsulation efficiency and potential damage to sensitive molecules. Hence the electrospray technique was investigated as an alternative. In this study, for the fabrication of solid LMP, the electrospray method was explored by varying different parameters such as flow rate and voltage. Scanning Electron Microscopy (SEM) was used to characterize the microparticles. Following the optimization of parameters, curcumin was loaded into the microparticle. Release studies of the curcumin loaded particles in simulated gastrointestinal fluids showed that the encapsulation was able to retard the release of curcumin in simulated gastric fluid (SGF) and release it in the simulated intestinal fluid (SIF). In order to prolong the release of curcumin, the curcumin loaded LMP were further encapsulated into floating particles that can act as a reservoir for LMP. Based on SEM images it was observed that the LMP were mainly localized on the surface of the floating microparticles. Further in vitro release studies on the floating particles need to be conducted to understand the behavior of LMP in the floating particles.
author2 Loo Say Chye Joachim
author_facet Loo Say Chye Joachim
Low, Celine Yan Jing
format Final Year Project
author Low, Celine Yan Jing
author_sort Low, Celine Yan Jing
title Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
title_short Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
title_full Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
title_fullStr Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
title_full_unstemmed Encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
title_sort encapsulating biopolymeric microparticles within floating capsules for oral delivery of drugs
publisher Nanyang Technological University
publishDate 2022
url https://hdl.handle.net/10356/156249
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