Delivery of Wnt inhibitor WIF1 via engineered polymeric microspheres promotes nerve regeneration after sciatic nerve crush

• Main Authors: Zheng, Na, Lin, Junquan, Chin, Jiah Shin, Wiraja, Christian, Xu, Chenjie, McGrouther, Duncan Angus, Chew, Sing Yian
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Article
• Language: English
• Published: 2022
• Subjects: Engineering::Bioengineering; Peripheral Nerve Injury; Nerve Guidance Conduits
• Online Access: https://hdl.handle.net/10356/156351
• Institution: Nanyang Technological University

Injuries within the peripheral nervous system (PNS) lead to sensory and motor deficits, as well as neuropathic pain, which strongly impair the life quality of patients. Although most current PNS injury treatment approaches focus on using growth factors/small molecules to stimulate the regrowth of th...