High glucose restraint of acetylcholine-induced keratinocyte epithelial-mesenchymal transition is mitigated by p38 inhibition

• Main Authors: Tan, Mark Wei Yi, Tan, Wei Ren, Kong, Ze Qing, Toh, Jun Hong, Wee, Jonathan Wei Kiat, Teo, Erica Mei Ling, Cheng, Hong Sheng, Wang, Xiaomeng, Tan, Nguan Soon
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Acetylcholine; Cell Function
• Online Access: https://hdl.handle.net/10356/157036
• Institution: Nanyang Technological University

Non-neuronal acetylcholine (Ach) plays important roles in various aspects of cell biology and homeostasis outside the neural system. Keratinocytes (KCs) have a functional cholinergic mechanism, suggesting that they respond to Ach. However, the physiological role and mechanism by which Ach modulates...