Development of an on-chip skin substitute tester for non-invasive wearable sensor for physiological signals monitoring

Microneedles (MNs) are one of the upcoming research interests for miniaturized technology for diagnostic testing, drug delivery system and biomedical research. With these micro-sized biotechnologies emerge the need for the development of skin-on- chip devices. These devices are biomimetic systems th...

Full description

Saved in:
Bibliographic Details
Main Author: Montoya, Maria Reina Katrina Martin
Other Authors: Poenar Daniel Puiu
Format: Final Year Project
Language:English
Published: Nanyang Technological University 2022
Subjects:
Online Access:https://hdl.handle.net/10356/158074
Tags: Add Tag
No Tags, Be the first to tag this record!
Institution: Nanyang Technological University
Language: English
Description
Summary:Microneedles (MNs) are one of the upcoming research interests for miniaturized technology for diagnostic testing, drug delivery system and biomedical research. With these micro-sized biotechnologies emerge the need for the development of skin-on- chip devices. These devices are biomimetic systems that are fabricated on microfluidic chips. Such systems replicate the tissue interface, mechanical properties, and functions of the skin. This report discusses the development of a polydimethylsiloxane (PDMS) skin-on- chip designed to conduct in-vitro testing for a non-invasive microneedle-based wearable sensor for continuous physiological signals monitoring. The fabricated skin- on-chip tester showed promising results for the measurement of glucose concentration at lower concentration values. Further development in modelling the skin barrier will allow for better replication of the skin for the skin-on-chip tester, hence allowing for more accurate testing of the viability of the MN sensor.