Ultrastructure and nuclear architecture of telomeric chromatin revealed by correlative light and electron microscopy

• Main Authors: Hübner, Barbara, von Otter, Eric, Ahsan, Bilal, Wee, Meiling, Henriksson, Sara, Ludwig, Alexander, Sandin, Sara
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Telomeres; Telomere Biology; Correlative Light and Electron Microscopy; Electron Tomography; FIB-SEM; Chromatin Structure
• Online Access: https://hdl.handle.net/10356/158886
• Institution: Nanyang Technological University

Telomeres, the ends of linear chromosomes, are composed of repetitive DNA sequences, histones and a protein complex called shelterin. How DNA is packaged at telomeres is an outstanding question in the field with significant implications for human health and disease. Here, we studied the architecture...