Microglia and CD206⁺ border-associated mouse macrophages maintain their embryonic origin during Alzheimer's disease

• Main Authors: Wu, Xiaoting, Saito, Takashi, Saido, Takaomi C., Barron, Anna M., Ruedl, Christiane
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Biological sciences; Alzheimer Disease; Amyloid Beta Protein
• Online Access: https://hdl.handle.net/10356/159385
• Institution: Nanyang Technological University

Brain microglia and border-associated macrophages (BAMs) display distinct spatial, developmental, and phenotypic features. Although at steady state, the origins of distinct brain macrophages are well-documented, the dynamics of their replenishment in neurodegenerative disorders remain elusive, parti...