The bacterial tyrosine kinase system CpsBCD governs the length of capsule polymers

• Main Authors: Nakamoto, Rei, Kwan, Jeric Mun Chung, Chin, Jasmine Fei Li, Ong, Hui Ting, Flores-Kim, Josue, Midonet, Caroline, VanNieuwenhze, Michael S., Guan, Xue Li, Sham, Lok-To
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Streptococcus Pneumoniae; Capsular Polysaccharide
• Online Access: https://hdl.handle.net/10356/159617
• Institution: Nanyang Technological University

Many pathogenic bacteria are encased in a layer of capsular polysaccharide (CPS). This layer is important for virulence by masking surface antigens, preventing opsonophagocytosis, and avoiding mucus entrapment. The bacterial tyrosine kinase (BY-kinase) regulates capsule synthesis and helps bacterial...