A PDZ protein GIPC3 positively modulates hedgehog signaling and melanoma growth

• Main Authors: Patmanathan, Sathya Narayanan, Tong, Bing Teck, Teo, Jackie Jia Hao, Ting, Jonathan Yong Zheng, Tan, Nguan Soon, Sim, Kenice Siew Hoon, Ta, Yng-Cun, Woo, Wei-Meng
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2022
• Subjects: Science::Medicine; Primary Cilia; Molecular-Cloning
• Online Access: https://hdl.handle.net/10356/159770
• Institution: Nanyang Technological University

The hedgehog (Hh) pathway is essential for animal development, but aberrant activation promotes cancer growth. In this study, we show that GIPC3, a PDZ domain-containing protein with putative adaptor protein function, positively modulates Hh target gene expression in normal fibroblasts and melanoma...